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At-Home Genetic Testing · Adults & Children · Simple Cheek Swab

MTHFR & COMT Genetic Tests

Explore two commonly studied genes involved in methylation-related biology. Choose MTHFR, COMT, or test both together for a broader view of folate processing and catecholamine metabolism.

CLIA-Certified Lab

Results Typically 2–5 Days

Educational Interpretation Included

Adults & Children

Private Online Results

Why most people choose the combo: MTHFR and COMT have different roles in methylation-related pathways. Testing both costs $189.99 — $70 less than purchasing the two $129.99 tests separately.

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HSA/FSA may be eligible depending on your plan. Available worldwide.

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MTHFR: C677T + A1298C

Commonly studied variants related to MTHFR enzyme activity and folate-related pathways.

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COMT: V158M

A functional COMT variant studied for differences in enzyme activity and catecholamine metabolism.

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Educational guidance included

Clear results and general interpretation to support conversations with your healthcare provider.

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Privacy first

Your results are delivered through a secure online dashboard and handled according to our privacy practices.

NY & MD residents: A special ordering process applies. See current ordering information.

For educational and informational purposes only. These tests are not intended to diagnose, treat, cure, prevent, or predict any disease or medical condition.

Why people explore MTHFR & COMT

Different questions can lead to the same starting point: understanding your genetics.

MTHFR and COMT testing provides information about specific genetic variants. It can add context to wellness and nutrition discussions, but it does not diagnose symptoms or medical conditions.

Already familiar

Methylation, MTHFR & COMT research

For people already reading about methylation pathways and looking for a focused test of MTHFR C677T/A1298C and COMT V158M.

Nutrition

Folate metabolism & one-carbon pathways

MTHFR participates in folate-related metabolism. Results can support informed conversations about nutrition and wellness with a qualified healthcare professional.

Pregnancy planning

Preconception & pregnancy nutrition

Some people explore MTHFR because folate metabolism is relevant to normal pregnancy nutrition. Genetic results do not measure fertility or predict pregnancy outcomes.

Neurotransmitter biology

Stress, focus & emotional processing research

COMT helps metabolize catecholamines, including dopamine. Research has examined COMT variation in cognitive and behavioral traits, but a COMT result is not a mental-health diagnosis.

Family genetics

Adults, children & inherited variants

The cheek-swab method can be used for adults and children. Testing shows inherited variants; it does not determine a child's health, behavior, or developmental outcome.

Attention & development

Questions about ADD/ADHD or developmental concerns

Some families encounter MTHFR or COMT while researching attention or development. These tests do not diagnose ADD/ADHD, autism, developmental delay, or learning conditions.

Important limitation

Questions about vaccines or immunization

MTHFR or COMT variants do not establish vaccine safety, predict vaccine reactions, or determine whether immunization is appropriate. Vaccination decisions should be made with a qualified healthcare professional.

Overall wellness

A clearer genetic baseline

For people who want a concise genetic snapshot that can be considered alongside health history, lifestyle, nutrition, labs, and professional medical guidance.

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Understanding the genes

MTHFR and COMT: two different roles in methylation-related biology.

Testing them together does not measure every part of methylation. It provides a broader genetic view than testing either of these two genes alone.

MTHFR

Methylenetetrahydrofolate reductase

MTHFR provides instructions for an enzyme involved in folate processing and one-carbon metabolism. These pathways support normal methylation chemistry and homocysteine-related metabolism.

The test evaluates two commonly studied variants:

C677T

A1298C

COMT

Catechol-O-methyltransferase

COMT provides instructions for an enzyme that transfers a methyl group to catechol compounds. It is one of the pathways involved in metabolism of catecholamines such as dopamine, epinephrine, and norepinephrine.

The test evaluates a widely studied functional variant:

V158M

MTHFR supports methyl-group availability

MTHFR participates in folate-dependent one-carbon metabolism, an upstream part of the biochemical network that supports normal methylation.

COMT uses methylation chemistry

COMT is a methyltransferase that uses S-adenosylmethionine (SAM) as a methyl donor when metabolizing catechol compounds.

Why the combo is our recommended option: the two tests answer different questions. MTHFR gives information about common folate-processing variants; COMT adds a functional variant involved in catecholamine metabolism. Together they provide a broader two-gene view for only $60 more than either single test.

Genetic testing is one piece of information. Complex outcomes such as fertility, mood, attention, development, medication response, and immune response are influenced by many genetic and non-genetic factors.

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Choose the right test for you

Three powerful options. One trusted team.

Not sure which test is right? Our experts are here to help — call us 7 days a week.

MTHFR Test

$129.99

$230.00

Best for

Ideal for first-time testers or those focused specifically on MTHFR and folate processing.

Order MTHFR Test →

⭐ Most Popular

MTHFR + COMT Combo

$189.99

$360.00

Most comprehensive

Save $70 vs. buying separately. The complete methylation picture for individuals who want the most comprehensive genetic insight.

Order Combo — Best Value →

COMT Test

$129.99

$230.00

Best for

Ideal for individuals focused on mental health, mood, cognitive performance, and stress response.

Order COMT Test →

Not sure which test is right for you? Call us — live support available 7 days a week.

Simple 3-step process

From home to answers.

No doctor visit. No needles. No waiting room.

Collect

A simple cheek swab at home. Non-invasive, painless, and safe for all ages — including babies and toddlers. No special preparation required.

Mail

Return your sample using the prepaid envelope included in every kit. No trips to the lab, no scheduling required. Just drop it in any mailbox.

Get Results

Results delivered securely to your online dashboard within 2–5 business days of lab receipt. Expert educational interpretation included — and a real expert available to call.

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What happens after you receive results

Most companies send you a report. We walk you through it.

Getting your results is just the beginning. Your report identifies the tested variants and includes general educational interpretation so you can understand what was measured and what the result means.

Step 1

Clear Variant Results

A straightforward explanation of the MTHFR and/or COMT variants tested and the genotype reported by the laboratory.

Step 2

Educational Context

General information about the biological pathways commonly discussed with these variants, written to support informed wellness conversations.

Step 3

Human Support

Phone support is available to help explain the report and answer general questions about what the genetic result does—and does not—show.

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Why MTHFR Doctors

Most companies deliver results.
We deliver guidance.

It's not just about your data. It's about understanding it.

Others

MTHFR Doctors

PDF Report

You get a file and you're on your own.

Expert Interpretation

Our team interprets your results in clear, actionable language.

Automated Results

Machines analyze your data with no human context.

Real Human Guidance

Get real answers from professionals who understand your situation.

Generic Recommendations

One-size-fits-all suggestions that may not apply to you.

Educational Next Steps

General wellness information to help frame conversations with your healthcare provider.

Limited Support

Email-only or limited access when you need help.

Expert Support 7 Days a Week

Our team is here by phone, email, or chat whenever you need us.

Long Wait Times

Weeks or months to receive results with no follow-up.

Results Typically in 2–5 Days

Private online delivery after the laboratory receives your specimen.

Customer reviews

What customers are saying

5.0

★★★★★

Based on verified purchases

★★★★★

"It was an easy to use test, received fast results and had a great 'live' personal phone call in response and support for interpretation of the test with the added support for ongoing questions!"

sleevesup

April 8, 2025

✓ Verified Purchase

★★★★★

"Excellent customer service, fast results. I was impressed by how straightforward the process was and how quickly I received support after getting my results."

Lisa Wright

February 13, 2019

✓ Verified Purchase

Have questions?

Frequently asked questions

What does the MTHFR test analyze?

The MTHFR test analyzes the C677T and A1298C variants. These are commonly studied variants related to MTHFR enzyme activity and folate-processing pathways.

What does the COMT test analyze?

The COMT test analyzes V158M, a widely studied functional variant associated with differences in COMT enzyme activity. COMT is involved in the metabolism of catecholamines such as dopamine, epinephrine, and norepinephrine.

Why test MTHFR and COMT together?

The genes have different roles. MTHFR participates in folate-dependent one-carbon metabolism, while COMT is a methyltransferase involved in catecholamine metabolism. Testing both provides a broader two-gene view than either single test. The combo is also $69.99 less than purchasing the two tests separately at current prices.

Can these tests diagnose anxiety, depression, ADD/ADHD, autism, developmental delay, or other conditions?

No. MTHFR and COMT variants may be studied in research involving many complex traits, but these tests do not diagnose, treat, prevent, or predict mental-health, neurological, developmental, or other medical conditions.

Can MTHFR or COMT results tell me whether vaccines are safe or whether someone will have a vaccine reaction?

No. These variants do not establish vaccine safety, predict vaccine reactions, or determine whether vaccination is appropriate. Immunization decisions should be discussed with a qualified healthcare professional using current clinical guidance.

Can this test tell me whether I am fertile or predict a pregnancy outcome?

No. MTHFR testing provides genetic information about folate-related pathways. It does not measure fertility and cannot predict conception, miscarriage, pregnancy complications, or pregnancy outcomes.

Can children use these tests?

The cheek-swab collection method is non-invasive and is offered for adults and children. Genetic testing in a child should be used as informational data and not as a substitute for pediatric or developmental evaluation.

Do I need a prescription?

No prescription is required for these at-home cheek-swab collection kits.

How long do results take?

Results are typically available within 2–5 business days after the laboratory receives the specimen. Shipping and transit time are separate.

Is my information kept private?

MTHFR Doctors states that it does not sell or share personal information or test results with third parties or insurance companies except as required by law. Results are delivered through a secure online dashboard.

Can I use HSA or FSA funds?

Eligibility depends on the specific plan. Check with your employer or plan administrator.

Is this a medical diagnostic test?

No. These tests are offered for educational and informational purposes and are not intended to diagnose, treat, cure, prevent, or predict a disease or medical condition.

Choose how much genetic information you want.

Start with one gene, or get MTHFR + COMT together for the broadest of the three options and the strongest value.

Choose Your Test ▾

For educational and informational purposes only. Not intended to diagnose, treat, cure, prevent, or predict any disease or medical condition. Results are not a substitute for professional medical advice.

MTHFR & COMT – Lab Tests

MTHFR & COMT Genetic Tests

Different questions can lead to the same starting point: understanding your genetics.

Methylation, MTHFR & COMT research

Folate metabolism & one-carbon pathways

Preconception & pregnancy nutrition

Stress, focus & emotional processing research

Adults, children & inherited variants

Questions about ADD/ADHD or developmental concerns

Questions about vaccines or immunization

A clearer genetic baseline

MTHFR and COMT: two different roles in methylation-related biology.

MTHFR

COMT

MTHFR supports methyl-group availability

COMT uses methylation chemistry

Three powerful options. One trusted team.

MTHFR Test

MTHFR + COMT Combo

COMT Test

From home to answers.

Collect

Mail

Get Results

Most companies send you a report. We walk you through it.

Clear Variant Results

Educational Context

Human Support

Most companies deliver results.We deliver guidance.

What customers are saying

Frequently asked questions

Choose how much genetic information you want.

Most companies deliver results.
We deliver guidance.