At-Home Genetic Testing · Adults & Children · Simple Cheek Swab
Explore two commonly studied genes involved in methylation-related biology. Choose MTHFR, COMT, or test both together for a broader view of folate processing and catecholamine metabolism.
HSA/FSA may be eligible depending on your plan. Available worldwide.
For educational and informational purposes only. These tests are not intended to diagnose, treat, cure, prevent, or predict any disease or medical condition.
Why people explore MTHFR & COMT
MTHFR and COMT testing provides information about specific genetic variants. It can add context to wellness and nutrition discussions, but it does not diagnose symptoms or medical conditions.
For people already reading about methylation pathways and looking for a focused test of MTHFR C677T/A1298C and COMT V158M.
MTHFR participates in folate-related metabolism. Results can support informed conversations about nutrition and wellness with a qualified healthcare professional.
Some people explore MTHFR because folate metabolism is relevant to normal pregnancy nutrition. Genetic results do not measure fertility or predict pregnancy outcomes.
COMT helps metabolize catecholamines, including dopamine. Research has examined COMT variation in cognitive and behavioral traits, but a COMT result is not a mental-health diagnosis.
The cheek-swab method can be used for adults and children. Testing shows inherited variants; it does not determine a child's health, behavior, or developmental outcome.
Some families encounter MTHFR or COMT while researching attention or development. These tests do not diagnose ADD/ADHD, autism, developmental delay, or learning conditions.
MTHFR or COMT variants do not establish vaccine safety, predict vaccine reactions, or determine whether immunization is appropriate. Vaccination decisions should be made with a qualified healthcare professional.
For people who want a concise genetic snapshot that can be considered alongside health history, lifestyle, nutrition, labs, and professional medical guidance.
Understanding the genes
Testing them together does not measure every part of methylation. It provides a broader genetic view than testing either of these two genes alone.
MTHFR provides instructions for an enzyme involved in folate processing and one-carbon metabolism. These pathways support normal methylation chemistry and homocysteine-related metabolism.
The test evaluates two commonly studied variants:
C677T A1298CCOMT provides instructions for an enzyme that transfers a methyl group to catechol compounds. It is one of the pathways involved in metabolism of catecholamines such as dopamine, epinephrine, and norepinephrine.
The test evaluates a widely studied functional variant:
V158MMTHFR participates in folate-dependent one-carbon metabolism, an upstream part of the biochemical network that supports normal methylation.
COMT is a methyltransferase that uses S-adenosylmethionine (SAM) as a methyl donor when metabolizing catechol compounds.
Choose the right test for you
Not sure which test is right? Our experts are here to help — call us 7 days a week.
Best for
Ideal for first-time testers or those focused specifically on MTHFR and folate processing.
Order MTHFR Test →Most comprehensive
Save $70 vs. buying separately. The complete methylation picture for individuals who want the most comprehensive genetic insight.
Order Combo — Best Value →Best for
Ideal for individuals focused on mental health, mood, cognitive performance, and stress response.
Order COMT Test →Not sure which test is right for you? Call us — live support available 7 days a week.
Simple 3-step process
No doctor visit. No needles. No waiting room.
A simple cheek swab at home. Non-invasive, painless, and safe for all ages — including babies and toddlers. No special preparation required.
Return your sample using the prepaid envelope included in every kit. No trips to the lab, no scheduling required. Just drop it in any mailbox.
Results delivered securely to your online dashboard within 2–5 business days of lab receipt. Expert educational interpretation included — and a real expert available to call.
What happens after you receive results
Getting your results is just the beginning. Your report identifies the tested variants and includes general educational interpretation so you can understand what was measured and what the result means.
Step 1
A straightforward explanation of the MTHFR and/or COMT variants tested and the genotype reported by the laboratory.
Step 2
General information about the biological pathways commonly discussed with these variants, written to support informed wellness conversations.
Step 3
Phone support is available to help explain the report and answer general questions about what the genetic result does—and does not—show.
Why MTHFR Doctors
It's not just about your data. It's about understanding it.
| Others | MTHFR Doctors | |
|---|---|---|
| PDF ReportYou get a file and you're on your own. |
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Expert InterpretationOur team interprets your results in clear, actionable language. |
| Automated ResultsMachines analyze your data with no human context. |
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Real Human GuidanceGet real answers from professionals who understand your situation. |
| Generic RecommendationsOne-size-fits-all suggestions that may not apply to you. |
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Educational Next StepsGeneral wellness information to help frame conversations with your healthcare provider. |
| Limited SupportEmail-only or limited access when you need help. |
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Expert Support 7 Days a WeekOur team is here by phone, email, or chat whenever you need us. |
| Long Wait TimesWeeks or months to receive results with no follow-up. |
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Results Typically in 2–5 DaysPrivate online delivery after the laboratory receives your specimen. |
Customer reviews
"It was an easy to use test, received fast results and had a great 'live' personal phone call in response and support for interpretation of the test with the added support for ongoing questions!"
"Excellent customer service, fast results. I was impressed by how straightforward the process was and how quickly I received support after getting my results."
Have questions?
Start with one gene, or get MTHFR + COMT together for the broadest of the three options and the strongest value.
For educational and informational purposes only. Not intended to diagnose, treat, cure, prevent, or predict any disease or medical condition. Results are not a substitute for professional medical advice.