The purpose of this article is to explain how your MTHFR (MethyleneTetraHydroFolate Reductase) gene mutation may affect your immune system, and how addressing your MTHFR may help you directly fight the coronavirus. Additionally, you will learn what you should do about your MTHFR mutation to be safe during these exceptional times. As it turns out, MTHFR and methylation are extremely important in fighting COVID-19. I am sure when many of you tried to learn more about MTHFR and your immune system, you got lost in heavy, complicated language that almost requires a PhD in biochemistry to understand it. Therefore, I will try to explain everything in simple language, whenever possible, except for when I quote sentences from research studies.

What is MTHFR (MethyleneTetraHydroFolate Reductase)?
MTHFR is a gene that activates an enzyme in our body responsible for converting the storage form of folate into the active form or methylated form of folate.  We don’t get active folate from food; it needs to be metabolized and broken down to a methylated form for use by our body. If you have a MTHFR gene without any mutations, your body has no problem to generating the methylated folate. However, if you have a MTHFR mutation, your body will partially lose its ability to generate methylated folate. Now let’s look at the statistics. Eighty percent of the population has at least one mutation in one of the two main alleles (positions) of the MTHFR gene. The main alleles are C677T and A1298C. Depending on the mutation, a person may lose a percentage of their ability to generate the methylated form of folate necessary to fuel the methylation process. The breakdown of this loss is 20 percent for a single mutation (heterozygous mutation) on the A1298C position to 70 percent for a double mutation (homozygous mutation) on the C677T position.

Now let’s understand what this means for your health and how it affects the ability of your body to protect against viruses. Methylated folate is the main ingredient needed to fuel a complex biochemical process called methylation. In simple technical terms, methylation creates methyl groups (CH3 – one carbon, three hydrogens) to be placed into molecules. When methylation happens, your body has the ability to control gene expression and suppress unwanted genes. Additionally, methylation controls intracellular detoxification and affects the immune response controlling T-cell production, fighting infections and viruses and regulating the immune response among other functions.

Now let’s understand, in simple terms, how methylation may protect us against viruses. Methylation protects us against bacteria and viruses in two different ways; the first is by supporting our immune system, which in turn protects us against viruses and bacteria. Second, the methyl groups (CH3) are placed into receptor sites of viruses to prevent them from replicating and from attaching themselves to our cells. The process of methylation itself fights viruses and prevents viruses from attacking our cells and from replicating.

I have created a short video to illustrate this process. I strongly recommend everyone watch this video.

An article by Leo Pruimboom – May 26, 2020, states, “The results by (Corley and Ndhlovu, 2020) reveal that the ACE2 gene activity, based on the methylation pattern of the several promotor CpG isles, is associated with age and gender. ACE2 is present in multiple human tissues and organs, including the lung, the gut, the liver, the pancreas, the brain, and blood. The methylation rate in lung epithelial cells was the lowest compared with all the other tissues, which suggests that lung tissue has the highest transcription and expression rate of ACE2. At the same time, it was evidenced that the ACE2 gene in neurons and leukocytes is hypermethylated and that the protein seems not to be expressed. Age correlates in this study with hypomethylation of the ACE2 gene in lung tissue, which could provide a partial explanation for aging as a risk factor for SARS-CoV-2 fatality, whereas male gender shows a trend in hypomethylation [5th paragraph]”.

In simple terms, if you have a healthy and strong methylation, then you have a much higher chance to neutralize the COVID-19 virus! 

I could list many more studies and articles here, but the bottom line is, you have to support your methylation!

Now, the new question is, how am I going to support my methylation? Below, I have listed several steps for you to take and have made many recommendations for you to follow to support your methylation.

Step one: Get tested for the MTHFR gene mutation right away. Our website provides a noninvasive MTHFR cheek swab home-testing kit that you may purchase without a doctor’s prescription. The test gives you results, usually within two weeks from the time we receive your specimen. The cheek swab saliva test is noninvasive, safe, and secure, and you can do it from the comfort of your home.

Why do you need to get tested? There are several possible mutations for the MTHFR gene, (six to be precise) and for each one, your body may need a different amount of methylated folate to support your methylation. We are talking about a very precise biochemical system in the body. For methylation to function properly, you need to have enough methylated folate but not too much. There is a fine line between hypermethylation (slightly higher methylation that makes your methylation wheel turn a little faster without any negative results) and overmethylation (your methylation is out of control and throws your body off, breaking down your health).

As mentioned previously, if your methylation is not supported, you are more prone to serious viral issues, and on top of it, your body is slow to produce the activated folate molecule. You have to do some biochemical work and, give your body some cofactors, such as B12, B6, B2, and folate, to push the methylation process along.

Now, you ordered your test. Should you wait for the results? Absolutely not!

Step 2: Start supplementing right away! Because we don’t know your mutation yet, or whether you have one, take the minimum dosage of methylated folate while waiting for your results. By taking the minimum dosage, you are beginning to support your methylation without running the risk of going into overmethylation.* Once you receive the results of your MTHFR gene test, you may adjust your intake of methylated folate according to your MTHFR mutations. I like a well-balanced formula that incorporates multiple B vitamins in addition to methylated folate (B9). Our methylation support formula contains: methylated folate (B9), methylated B12, B6, vitamin C, vitamin E, riboflavin (B2), magnesium, Choline, trimethylglycine, betaine, MSM, and beet (root). I have found this to be a well-rounded formula tolerated well by most patients.

Below is a recommendation table of our product of choice to support your methylation:

Directions for our methylation support dosage according to your MTHFR mutations (adults and children over twelve years of age):

  • No mutations or MTHFR A1298C heterozygous (one mutation) take one capsule once a day with a meal;
  • MTHFR A1298C homozygous (two mutations) or MTHFR C677T heterozygous (one mutation) take two capsules per day with meals; or
  • MTHFR C677T homozygous (two mutations) or compound heterozygous (one mutation of C677T and one of A1298C) take 3 capsules per day with meals.

Alternatively, you can take it as directed by your healthcare professional. For children less than twelve years old, consult their pediatrician.

Always increase the amount slowly. Start with one capsule per day. You may increase the dosage by one capsule every three days according to your MTHFR mutations; however, do-not exceed the daily recommended for your MTHFR mutation. If you have any unwanted reactions, stop taking the supplement immediately, and consult your healthcare professional for advice.

To precisely understand how much folate you really need, I have written an article that teaches you how to calculate folate levels based on your MTHFR mutation. You would need to get a blood test for serum folate to calculate it. The test should be conducted with at least eight hours fasting and without taking any supplements for at least three days previously. I recommend you ask a MTHFR expert to help you interpret the results and to make sure you do not make a mistake. However, this article explains in detail what is needed.

Let me underline a very important point here:  Your genes will never change, and this means if you have a MTHFR gene mutation, then you will carry this for the rest of your life. Additionally, this means you will need to supplement your diet for the rest of your life with a methylated form of folate, according to your own MTHFR mutation. During this time with the coronavirus, I recommend you take a little extra methylated folate to keep your body on a slightly hypermethylated state without going into overmethylation.

Step three: What else supports your methylation? Vitamin D

A very recent study by Ilie and Smith (2019) shows that the low levels of vitamin D in European countries correlates with mortality rates from COVID-19, which strengthens my recommendation for the intake of vitamin D from a functional level of 60 to 120.  I like to see an ideal level between 80 and 100. Additionally, vitamin D has been shown in many studies to be anticancer (Castronovo 2015,  Skrajnowska 2019,  Sun 2017). Aside from getting vitamin D through food and sunlight, I always recommend my patients a liquid form of vitamin D intake between 5,000 IU to 10,000 IU per day, depending on various factors, such as, MTHFR mutation, risk factors for coronavirus, vitamin D levels, and blood chemistry work.

Step four: Another nutrient that has been found by research to support methylation is curcumin. A great study by Hassan 2019 shows how curcumin inhibits DNMT activities and modifies the pattern of DNA methylation. Another example is the 2015 study by Boyanapalli & Kong that shows the epigenetic regulatory mechanisms of curcumin.

There are also more than 1,500 papers published on curcumin that has revealed that curcumin has a potential in the treatment of wide variety of inflammatory diseases including cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s disease, and psoriasis.

The benefits of curcumin could be the subject of a whole article. However, what really matters for the purpose of this article, is that curcumin supports your methylation. Just pay attention to your sources and how they extract the curcumin out of turmeric. There are many curcumin products on the market so be careful when you choose this supplement. Studies have shown that when the curcumin is standardized to 95 percent curcuminoids and mixed at the right proportion with black pepper, it is the right recipe to support methylation as well as to benefit from the anti-inflammatory properties. I personally like and recommend our product: (Turmeric/Curcumin) to my patients because of the quality of the ingredients and the research behind this brand.

Step five: Take glutathione. The by-product of methylation is glutathione and if there is a chance you have a methylation that is not working well, chances are you don’t have enough glutathione in your body and you should also supplement with glutathione.

Glutathione is the major anti-oxidant in the body. In addition to have an anti-inflammatory effect, glutathione also supports the immune system. Not all glutathione products are the same. Make sure you take the form called S-Acetyl L-Glutathione.

For convenience we carry glutathione in capsules and patches. Our liquid form is almost as strong as an intravenous glutathione, with one difference; the intravenous form usually comes with strong side-effects. When taking this supplement orally, there are no side effects.

Glutathione is rapidly absorbed by the liver in our body so I suggest that whenever taking glutathione it is important to take precursors to glutathione to help your body make more of it. We have a glutathione builder product that contains the main element necessary to help the body to produce glutathione: N-Acetyl L-Cysteine.

Step six: As a Chinese medicine practitioner I have to mention about the power of Chinese herbs, especially when it comes to strengthening the immune system. I have developed an herbal tea called Immune Boost. This herbal tea contains natural herbs that strengthen the immune system and have strong anti-viral properties. We have been able to assemble a formula that is strong and delicious at the same time. The ingredients are: Astragalus Root, Liquorice Root, Ginger Root, Jujube Fruit, Goji Berry.

Step seven: Supplementation is a must for your methylation. However, you still need to have a balanced, healthy diet. Make sure to include dark green leafy vegetables in your diet, which provide you with natural folate (a methyl donor). Eat whole foods, and avoid processed foods. Review your life-style and see where you can make positive changes. Avoiding excessive alcohol or quitting smoking will remove tremendous pressure from your body.

Step eight: Exercise is and always has been one of the key components for longevity. With our focus on supporting methylation to fight the coronavirus, we have to include regular exercise in the recommendations. According to Voisin 2015, an analysis of twenty five studies has shown that acute and chronic exercise significantly affects DNA methylation.

When I talk about exercise, I include any physical activity that gets your muscles to work and promotes your blood circulation. It does not have to be, in a traditional sense, going to a gym or riding a bicycle. Other forms of nontraditional exercise may include gardening, dancing, cleaning (yes, even cleaning your home if you have to bend and stretch your body), hiking, fixing things around your house, and more. The key is consistency. As long as you do one of these things on a regular basis, you will support your methylation. Exercising three to four times per week is ideal.

Step nine: While we are talking about our life-style, which is the base of epigenetics, we should point out a very important factor that will reduce your methylation, stress! According to Harrison Wein, Ph.D., studies have shown that stress hormones called glucocorticoids alter gene expression in the brain. The researchers added that corticosterone decreases Fkbp5 methylation levels. I recommend everyone start activities that brings joy to your lives. At least once per week, do one thing that you love to do. You cannot underestimate the power of happiness! Additionally, I recommend small activities on a daily basis, such as meditation, breathing exercises, yoga, and positive affirmation. All you need is five to fifteen minutes a day to make a great change in your life and health.

Step ten: One last thing on this subject, gratitude! This is, perhaps, the most important of all. Every day you should give thanks to God or the universe, whatever is the most appropriate to your belief system. Give thanks to everything you have, and give thanks for everything that happens to you. Trust God or the universe that whatever happens in your life will eventually lead to something better. If you lose your job, give thanks that perhaps a better opportunity will show up in your life and that will eventually lead to something bigger and better.

A summary of the tips to support methylation to fight COVID-19:

*For the vast majority of the population, the minimum dosage of methylated folate will not throw the body into overmethylation however, on rare occasions the patient may only handle a small portion of the minimum dosage or none at all. Usually, in these cases, as soon as the patient starts taking methylated folate, they have unwanted side effects, such as fatigue, diarrhea, anxiety, and more. If that happens, stop taking methylated folate immediately and, take a small amount of niacin (100 mg), which will neutralize the methylated folate, and consult your doctor. In these cases, you should only take supplements under the care of a doctor who understands methylation.

About The Author

14 thoughts on “Coronavirus and MTHFR – The Best Prevention Strategy against COVID-19”

  1. Hello Dr. Miranda,
    Thank you for your videos. I am homozygous for the C677T gene. My Dr put me on 10 mg Throrne 5 MTHF and said it would help. I found out through the Genesight test my psychiatrist did for matching medication. I have suffered from anxiety my whole life and low lying depression. I had panic attacks in my early 30’s after giving birth. I am now 57 and after the 2nd vaccine in March of last year I developed tinnitus. It has disrupted my whole life. I fell into the highest anxiety and deepest depression Ive ever known and was suicidal for months last year. My psychiatrist is the one who put me on the Methylfolate but since I’ve started taking it I have not seen the changes he said I should see. (im still anxious and depressed.) I am also taking Nortriptyline and Klonopin which I want to get off the benzo as I’ve been on them for almost a year, but they help me sleep with this tinnitus. I have never been through anything this difficult before. But my husband was really concerned my psychiatrist has me on so many supplements and we have read that not being on the right amount of metylfolate can cause more issues ( as you’ve said in your aritcles/videos.) Ive asked my doctor and he dismisses me and says he knows what hes doing. He can be very difficult to work with. My last labwork said my folate serum was >24 but when I called the lab to get the exact number they said my doctor would have to call. I can’t ask him as he wouldnt do it. My Vit D is 44 and my B12 was 785. These were all taken fasting. I just need help to know if the amount Im on is in excess. I also take a multi vitamin he prescribed that has Boioactivefolate + B12 It says Folate (as Folic acid and calcium L-5 methyltetrhydrofolate Magnafolate C). I hope you can help me. I am losing hope of getting better. Thank you.

  2. I am very grateful to come upon this information site.
    Both of my daughters have MTHFR..on both sides, from me, their mother and also from their father, they have had many health problems.
    I am wondering if getting “Covid Vaccinated” is going to be harmful to them. I can’t seem to get a straight answer anywhere.
    Does anyone know or has anyone come across any useful information on this?

  3. Kelly, Jeanne and Christine

    I do think whatever driving force landed me on the site and your comments. I to have done my own research as it’s been years since I found a doctor that could actually help with any of my progressively getting worse problems. I started my own self treatment my own research into why I have psoriasis why my ass man mysteriously disappeared for the period of three years my ongoing Gerd that the only thing the doctors wanted to do for me was prescribe Nexium Prilosec or protonic‘s none of them seem to want to get down to the nitty-gritty as to why I have these problems now I understand more than I ever have. I’ve not had one Prilosec or Nexium since April I have not needed an antacid or something for my Gerd since April my asthma is finally getting somewhat under control . So after learning everything that I’ve learned about the C677T which I have two copies of that and the MTHFR gene I started with daily cleansing and detoxification then I did a parasite cleanse and still doing the parasite cleanse as I’m finding relief with it I cured my stomach problems with virgin unprocessed coconut oil that took about 10 days. Also with the coconut oil I believe it healed candida I have a growth from years of being prescribed prednisone. Have a yet a doctor that will actually do any of the tests that I request which is quite frustrating but I’m now starting to implement the supplements so I just wanna make sure I get the right amounts and for that it takes a blood test to at least know where I’m at so still searching for that doctor hopefully I find one soon if not I’m just gonna shoot for the lowest dose and go from there and how I feel. It’s extremely frustrating that in 26 years I have not been able to find a physician that will listen to my problems listen to my concerns and actually work with me in my treatment they don’t seem to care if I know or understand what’s going on they just want to do things that I feel are unnecessary and put me on drugs that are absolutely unnecessary. I was told when I was in the hospital with my youngest child after her birth that I had a double copy of the C677TG notation and they told me that I just needed to take folic acid and that was the only thing that they told me. I’m glad I decided to get my full medical records because when I read those that’s when it refresh my memory of having that gene you Tatian so I decided to look into it a little bit further and I’m glad I did! I’ve had asthma since I was two I developed psoriasis at age of 34 I’ve had hypertension since I was 19 and I developed stomach problems since I was 22. When my stomach problems got really bad in January and I went to the doctor and they just wanted to switch antacids on me that’s when I threw my hands in the air and said no that’s OK I’ll take care of it myself and have had great success with just doing a cleansing not only do I feel better but the fatigue that I have been experiencing has went away which is amazing in and of it’s self because I’ve been suffering with the fatigue for years since at least 2013. Starting to experience arthritis or psoriatic arthritis I’m not sure which so that also has gone away so I’m excited to start supplementing to see if that reads my body of the psoriasis and a high blood pressure so fingers crossed

  4. Hi Steven,

    I already had COVID and recovered. I would like to get the antibody test but do you recommend getting vaccinated? I have double mutation C677T.

    1. I know you are specifically asking Steven – but I’d like to leave some feedback for you to consider. I have taken the past 18 months & researched a lot about this shot many are calling a vaccine & would prefer after much studying & listening to many doctors to call it a gene therapy. Many can’t speak up about it or give their advice without having their medical practice destroyed. With all the synthetic & many not so safe ingredients in the Gene therapy & knowing that MTHFR causes the body the inability to detox correctly – one should take time to also research to know for themselves if they feel it would be safe for them or not. The spike proteins & the way it has been created it is spreading throughout the body – once it is in the body there is no natural way of detoxing it. It doesn’t prevent one from getting the virus, many are having horrible reactions from the injection. There are many reports on VAERS & #protectyourfamily to read of people’s experiences… being that up to 80% of the population has MTHFR, whose to say it will be safe for Every single body!! Consider using natural alternatives as a prophylactic & prevention with the Vit D, Vit C, Zinc, Quinine, Vit D & if needed use Ivermectin or contact the front line doctors for HCQ. DO all the things recommended in this article with sleep, exercise, avoid stress, take the supplements, eat good food & you will build the natural immunity… the shot is destroying T cells – not something those with MTHFR should be jumping to tangle with if they want to keep their immune systems strong. JMO – Best of luck.

      1. Christine Seumanutafa


        I am in agreement with you on this. I have C677T and have had blood clots in the past. I have also chosen not to take the vaccine, as I see it to be more of a risk than a benefit. Knowing that the spike protein is (“a pathogenic protein. It is a toxin and can cause damage in our body if it gets into circulation”-Byram Bridle Immunologist and associate professor at University of Guelph,Ontatrio cited by Lifesite News) the driving force for the vascular and inflammatory events in COVID 19 virus ( ), and understanding that the spike protein is the only part of the Sars-CoV-2 virus that is used in the Pfizer and Moderna vaccines, and the over 650,075 (as of August 23, 2021) reports from VAERS (CDC site for surveillance and data collection for vaccine adverse events, and according to the CDC “The strengths of VAERS are that it is national in scope and can quickly provide an early warning of a safety problem with a vaccine…VAERS is designed to rapidly detect unusual or unexpected patterns of adverse events, also known as ‘safety signals'”), one should be able to see the correlation between spike protein (adheres to Ace2 receptors and causes damage to cells-inflammatory and vascular disorders) in the virus and the same exact spike protein in the vaccine (regardless that they are wrapped in lipids for distribution.) causing the inflammatory and vascular injuries like thrombocytopenia, strokes, Myocarditis, blood clotting. The spike protein have been found to adhere to organs and found in blood plasma. According to Byram Bridle ( see above) when the spike protein attaches itself to specific ACE2 receptors that are on blood platelets and cells lining the blood vessels, it can do one of two things “It can either cause platelets to clump and that can lead to clotting. That is exactly why we’ve been seeing clotting disorders associated with these vaccines. It can also lead to bleeding”. It also explains spike protein circulation causing heart problems, i.e, Myocarditis in youths. Stephanie Seneff a senior research scientist at MIT, stated the spike protein is being shed into the adrenal glands then into the blood stream, causing systemic damage.

        To infer that anyone who is at risk of severe illness from covid 19 should get the vaccine, and deny the risk from the vaccines in that same population is quite irresponsible on the part of any doctor. To ignore the correlation or causation of the vaccine and adverse events/deaths is criminal on the part of the CDC, FDA, Pfizer, and our doctors. Basic math…VAERS reports of 650,000 post covid vaccination adverse events/deaths, all having one thing in common…a covid 19 vaccine. Is that not a common factor?

        Most doctors refuse to look at MTHFR mutations orconcern themselves with the impact these mutations have on their patients. They believe the study behind MTHFR is false and has no bearing on health. I take this very seriously, and have had to fight for medical exemption. My daughter is homozygous for MTHFR C677T as well, and her doctors refuse to acknowledge it as an issue. Her pediatric group has stated they know very little about this, and believe that all kids should get this vaccine. They believe it is a cure, which has been proven to be false.

        We need to choose what is best for our own bodies and make informed decisions, do our own detective work and look at articles, studies, data which will help us be more informed and understand what we are facing.

        1. Jeanna and Christine,

          I am so glad I stumbled on this page and have found others who conduct their own research and have arrived at the same conclusions. It is refreshing to see that not everyone is blindly following the ‘science’ around these drugs. I cannot, in good conscience, call these drugs vaccines. They do not prevent contraction or spread of the virus and to both of your points, it only protects against one aspect of the virus, S1/S2 protein, and not the entire virus makeup. It is also important to note, the S1/S2 protein was the gain of function focus from early 2000’s through 2014 when moratorium was put in place around gain of function research until 2017. Gain of function research focused on making the S1/S2 protein more transmissible (increased transmission function) in humans.

          I think it is important to note as well the COVID infection has a 98% survivability rate across the world. If you look at metrics from other countries, where they accurately report out infection, death, and recovery rates you will see a very high recovery rate (again upwards of 98-99% of infected are recovering from virus), which lends one to question why it is so important to take this drug, when it only reduces impact of the infection and does not prevent infection or spread. I would also like the medical community to further expand on how the ‘vaccinated’ transmit a variation of the virus. Typically, if you come into contact with a virus you naturally ‘shed’ pieces of the virus through sneezing, coughing, breathing, etc. With this ‘vaccination’ those receiving the shot transmit to others around them versus shedding from natural infection. So they are spreading the virus, but not the full virus, which may be why we’re seeing these variations. Which again ties back to the gain of function around the S1/S2 protein.

    1. Steven,
      The coronavirus is a serious and dangerous threat. I recommend taking the vaccine and taking methylated folate with methylated B12 and vitamin D and K. This way you are supporting your methylation at the same time. You should know your MTHFR status so you can take the right amount of folate. Below are links of the products I recommend: (Folate and B12) (D+K in capsules) or (D+K in liquid)

  5. Hi,
    I was diagnosed with MTHFR some years ago and don’t remember the details on the gene mutation. However, I have had symptoms since I was a child, as I used to faint, have digestive issues, extreme migraines, depression, fatigue and endometriosis. As an adult, I am not able to conceive, due to complications and scar tissue from the endometriosis.
    In June of 2020, I was diagnosed with COVID. My symptoms were mild.. if any at all. The main symptom was the fatigue and the headache, which lasted for more than a week. There was no fever, no difficulty breathing… not too bad. When I did feel congested, or stuffed up, I would go outside and sit in the sun. It was the strangest thing, as it seemed to ‘melt it all away’. June in North-West Arizona is HOT!! Reading this article, I related to so much of the information and can attest that Vitamin D is VITAL in recovery. Also, foods with potassium and vitamin C (apricots, bananas, pineapple and mango) helped relieve my COVID symptoms.
    Hope all is well, stay safe!

  6. I was tested by ARUP Laboratories in Salt Lake City, Utah. The report came back that I have MTHFR mutation:
    c.1286A>C HOMOZYGOUS. I have had terrible MTHFR symptoms through out my entire life including anemia, mental health issues, inability to conceive, fainting and digestive problems. I was born in 1940.
    I had to find what was causing my problems and started by looking at my family – there was no doubt that these symptoms hounded others in my family, therefore, I had and the genetic tests done.
    Through much research, I started taking Methylcobalamin B-12 and like a miracle in no time my symptoms were gone. I have had up my dose under my doctor’s orders when symptoms start reappearing.
    I read your article and appreciate your information. My doctor put me on vitamin D.
    Thanks, Dorie Tiseth

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