COMT Test – V158M

The COMT gene provides instructions for producing the catechol-O-methyltransferase enzyme, which plays a role in the breakdown of certain neurotransmitters and hormone-related compounds in the body. Different forms of this enzyme are produced in various tissues, including the brain and other organs.

The COMT V158M variant has been studied in relation to differences in enzyme activity and methylation-related pathways. Some individuals choose to learn more about this variant as part of their personal wellness and genetic education.

Individuals considering hormone-related therapies or with questions about their personal or family health history should consult with a qualified healthcare professional.

Available worldwide.

Includes physician-reviewed educational information and general results interpretation to help you better understand your results and support discussions with your healthcare provider.

Reliable and Confidential Testing: Testing is performed by a CLIA-certified laboratory to help ensure quality and confidentiality. Results are typically available within approximately 2-5 days after our laboratory receives your specimen.

Some individuals choose to test both COMT and MTHFR together because these genes are commonly discussed in relation to methylation pathways and folate metabolism. Learning about both variants may provide additional educational insight into individual genetic differences.

Behavioral Wellness Information

The COMT (Catechol-O-Methyltransferase) gene provides instructions for producing an enzyme involved in the breakdown of certain neurotransmitters and hormone-related compounds in the body. Research has identified common genetic variations in the COMT gene, including the V158M variant, which may influence enzyme activity levels.

COMT activity has been studied in relation to cognitive processing, stress response, and neurotransmitter metabolism. Different genetic variants may be associated with differences in how individuals process certain naturally occurring brain chemicals. Some studies suggest that individuals with different COMT variants may exhibit varying responses to stress, focus, and emotional processing, although individual experiences can vary widely.

Mental Wellness Research

Genetic variations in the COMT gene have been studied in scientific literature for potential associations with behavioral and mental wellness traits. Researchers have explored possible relationships between COMT variants and a variety of neurological and psychological conditions in certain populations. However, genetic testing alone is not intended to diagnose, treat, prevent, or predict any medical or mental health condition.

Neurological and Pain Research Information

COMT gene variants have also been studied in relation to neurotransmitter metabolism and pain perception. Scientific research has explored how differences in COMT enzyme activity may influence individual responses related to discomfort sensitivity and neurological pathways. Researchers have additionally investigated how COMT variations may affect responses to certain therapies involving neurotransmitter-related pathways.

This test is intended for educational and informational purposes only and should be discussed with a qualified healthcare professional for personalized guidance.

Many individuals choose to test both MTHFR and COMT together because these genes are commonly discussed in relation to methylation pathways. Our combo package includes both tests at a discounted price.

 

Recommended Tests

1. The MTHFR gene is commonly discussed in relation to methylation pathways and folate metabolism. Methylation is involved in many normal biological processes, including cellular function and gene regulation. Many individuals choose to learn more about their MTHFR status as part of their personal wellness and genetic education. You may order your MTHFR test here.
2. Cortisol is a hormone involved in the body’s natural stress response and daily biological rhythms. Some individuals choose to evaluate cortisol levels alongside methylation-related genetic testing as part of a broader wellness assessment. Since cortisol levels naturally fluctuate throughout the day, a four-times-per-day saliva collection method may provide additional insight into normal daily cortisol patterns. You may order your cortisol test here.

 

We offer free international shipping for our COMT test to customers worldwide.

Orders ship from California. Please allow an additional 1–2 business days for processing. Expedited shipping options are available.

For international orders, estimated delivery times may range from approximately 2–4 weeks depending on destination and customs processing.

Disclaimer: This test was developed for educational and informational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease or medical condition.